Dr. Mike L. Franklin, Résumé



Summary of Professional Experience


Expertise in four major scientific areas: Analytical Chemistry (Spectochemistry and Electronics Instrumentation), Microscopy (Scanning Electron Microscopy-Energy Dispersive X-ray analysis), Mechanical Engineering, and Materials Science. Over 30 years experience in problem-solving within the Pharmaceutical Industry with considerable experience in pharmaceutical aerosol measurement and development of patient drug delivery systems. Designed, fabricated, and employed several systems for small-quantity powder characterization such as particle size, shape, compaction-density, and flow. Considerable experience in Solid State Chemistry (Physical Properties) measurements: X-ray Diffraction, Infrared Spectroscopy, Thermal Analysis, Vapor Sorption, Density, and Particle Size Distribution and Morphology (size, shape, & surface roughness) Determinations.


Selected Project Experience


Developed Advanced Dose Delivery Systems for Metered Dose Inhaler (MDI) devices

  • Microprocessor Controlled--electronic Metered Dose Inhaler (e-MDI)
  • Project Team Leader for Advanced Technology Valve (2 MDI valve patents awarded)
  • Developed Advanced Manufacturing and Surface Modifications for MDI components
  • Invented & Fabricated Micro Residue-On-Ignition (ROI) for MDI component analysis

Designed and Developed Micro-Metrics Systems for small-quantity powder analysis

  • Microsieve & MicroRiffler systems developed and applied
  • Metered Aerosol Disperser (MAD) unit for powder sample collection (Patent published)
  • Truncated Graduated Cylinder-Dynamic Tapped Density system applied company-wide
  • Invented Vibrating Orifice Flow (VOF) instrument for better powder-flow measurements


Senior Research Chemical Engineer-Senior Research Scientist, Contractor

Research Triangle Institute (RTI) International, Research Triangle Park (RTP), NC, Center for Aerosol Technology

(5 years experience, 5 patent disclosures, 2004-Present)

Developed microprocessor controlled-Metered Dose Inhaler system for more efficient and more patient compliant delivery of asthma medication by the inhalation route. Instrumental in justifying, acquiring, and establishing an Environmental-Scanning Electron Microscope/Energy Dispersive X-ray (E-SEM/EDX) capability at RTI to support Nano-Spinning Technology and Materials Science Research and Development.

Director in Physical Properties

GlaxoSmithKline, RTP, NC

(3 years experience, developed 4 micrometrics devices & one patent submission)

Directed a 3-Person Group in a Particle Characterization Area (morphology = size, shape, & surface roughness), Co-led/trained a joint 9-member Interdepartmental Microscopy Team including:  Visible, Scanning Electron Microscopy (SEM), Environmental SEM, & Energy Dispersive X-ray (EDX) Analysis to support solid state chemistry characterization of drugs and excipients--15 years cumulative experience.  Designed & Developed Micrometerics Systems for small-quantity powder analysis:   Micro Residue On Ignition (ROI), Metered Aerosol Disperser (MAD), Truncated Graduated Cylinder-Dynamic Tapped Density, & Micro Vibrating Orifice Flow (VOF) instrument.  Helped by consulting for about 50 others in problem–solving using Invention Machine software applications and Innovation Center resources.

Principal Research Investigator

Glaxo/GlaxoWellcome, Research Triangle Park, NC

(12 years of effort, 2 patents, and 9 publications/outside presentations)

Developed and trained an Interdepartmental Solid State Chemistry (SSC) Team as Leader. SSC Team Members included about 10 scientists with expertise in Microscopies of Various Types, Energy Dispersive X-ray Analysis, Atomic Spectrochemistry, and Powder X-Ray Diffraction--3 year experience)  Led a 7-member multidisciplinary Analytical Chemistry/Sciences Department Group which utilized Scanning Electron Microscopy / Energy Dispersive X-Ray Analysis, Optical Microscopy, Powder X-Ray Diffraction, Atomic Spectrochemistry (AA & ICP), Robotics and Automation Area, Design-Machine Shop, and Electronics Instrumentation Area to perform creative problem-solving and instrument development in pharmaceutics--9 years of work (MAST System, Microsieve System & MicroRiffler Units are examples)  Identifed and championed technologies for particle size measurements and pharmaceutical Novel Oral Dosage Forms such as HydroDynamic Chromatography, Small-Scale Capsule-Filling, Pin-Milling, Web Delivery System, Inhalation Product Devices, etc.  Led 9-member team in developing advanced technology metered aerosol valves (2 patents).

Senior Scientist / Group Leader / Department Head

Hoffmann LaRoche, Nutley, NJ

(14 years experience & 5 patents)

Managed and provided technical leadership for a 16-member interdisciplinary department called Advanced Technology which supplied the novel instrumentation and technology development needs of the entire US Roche company (Clinical Diagnostics, Pharmaceuticals, & Chemical Divisions).

Assistant Professor of Analytical Chemistry

University of Missouri, Columbia, MO

(2 years of work, 3 grants written & funded, 2 publications)

Directed graduate research, taught both  10's of graduate students and 100's of undergraduates, acquired research grants in Biological Trace Metals Analysis.

Instructor in Pediatrics

University of Colorado Medical Center, Denver, CO

(2 years experience, 3 publications--work used by National Academy of Sciences to help set zinc MDR)

Introduced advanced spectrochemical instrumentation to pediatrics research on nutritional trace metals analysis, taught medical students analytical instrumentation.

NASA U. S. Army Assignee as a Captain

Ordnance Corps, Glenn (Lewis) Research Center, Cleveland, OH

(2 year assignment 1969-1970, 3 publications)

Spectrochemical Analysis and Instrumentation Development for Materials Science/Metallurgy during the U. S. Space Apollo (man-to-the-moon) Program.


EDUCATION AND TRAINING


  • Scanning Electron Microscopy and X-Ray Micro-Analysis Training, Lehigh University, Bethlehem, PA (Advanced course-1996, basic course-1987);

  • Clean Room Aerosol Technology Course, University of Minnesota, Minneapolis, MN (1983);

  • Laboratory Director Specialty License in Clinical Chemistry, State Board of Medical Examiners, Trenton, NJ (1982-89);

  • Toxicology of Therapeutic Drugs and Trace Metals, American Association of Clinical Chemistry, NY, NY (1977);

  • Diplomate #452 American Board of Clinical Chemistry-highest certification in Clinical Chemistry (1976).

  • Ph. D. in Analytical Chemistry, University of Illinois, Urbana, Illinois, (Feb. 1969); Graduate GPA 4.7/5.0; Dissertation:  The Spectrochemical Study of Energy Coupling to a Ruby LASER Induced Vapor Plume by Sub-Microsecond Time and Space Resolution - Research Director:  Professor Howard V. Malmstadt, creator of  "Electronics for Scientists" programs and courses.

  • MS in Chemistry, Atomic Spectroscopy, Senior Teaching Fellow for Electronics for Scientists courses (10 sessions - record holder), University of Illinois (Aug. 1966);

  • AB with Honors; "The Outstanding Indiana University Chemistry Undergraduate of 1964," Indiana University, Bloomington, IN, (Selected by PLU Chemistry Honorary); Award Plaque hanging in IU Chemistry Library; Undergraduate Chemistry GPA 3.9/4.0


Professional Associations


  • Adjunct Professor at North Carolina State University, Department of Biological and Agricultural Engineering, College of Agriculture and Life Sciences, January 2008-present.

  • Sigma Xi-The Scientific Research Society Life Member (publishes the American Scientist Journal), American Chemical Society (ACS) 40 year member, Sigma Pi Sigma Physics Honor Society Member, Microscope Society of America (MSA) Member (publishes Microscopy and Microanalysis Journal).


Professional Service


  • American Chemical Society VIP (Volunteers In Public) Outreach participation - more than 25 years of Science lectures and demonstrations/presentations to students at elementary, middle, and high school levels reaching 100 to 700 students per year.

  • Annual Guest lecturer at North Carolina State University (NCSU) in the Biological and Agricultural Engineering (BAE) Department from 2004-Present;

  • Honcho for Antique Farm Machinery Building Exhibit from 2006-Present, NC State Fair; Advisory Board Member for BAE Department at NCSU (2005-2010).


Seminars and Courses Taught


  • Inventiveness and Creativity Seminars taught at NC State University, Biological & Agricultural Engineering from 2008 to present as Adjunct Professor

  • Pharmaceutics Particle Size Measurements Seminar taught to over 100 GSK colleagues in 2000

  • Scanning Electron Microanalysis Training Seminars given to over 20 GSK scientists in groups of 2 to 5 from 1990 to 2002

  • Solid State Chemistry Physical Properties 3-day training seminar taught to 65 Glaxo scientists with Steven Byrn in 1991


  • Dr. Mike L. Franklin
    Ph.D, Analytical Chemistry
    mike@mikefranklinconsulting.com